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EMIDONE (Domperidone) Suspension 120ml (1mg/ml)

DRUG CATEGORY: Antidopaminergic / Gastroprokinetic

MECHANISM OF ACTION: The gastroprokinetic properties are related to its peripheral dopamine receptor blocking properties. Domperidone facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone.

INDICATIONS: Acute nausea and vomiting, Dyspepsia, Functional dyspepsia, Gastric distension pain due to pressure on the stomach, Gastro-oesophageal reflux disease, Nausea and vomiting, Non-ulcer dyspepsia, Reflux oesophagitis.

DOSAGE AND ADMINISTRATION: Adults: 20mg (20ml of Suspension) 3 – 4 times daily, 15 to 30 minutes before meals Children: 5mg (5ml of Suspension) per 10kg body weight, 3 – 4 times per day, 15 to 30 minutes before meals Chronic conditions (Mainly dyspepsia): Adults: 10mg taken 3 times daily, 15 to 30minutes before meals. The dosage may be doubled in severe cases Children: 2.5mg (2.5ml Suspension) per 10kg body weight taken 3times daily, 15 to 30 minutes before meals and, if necessary before retiring to bed

PRESENTATION: EMIDONE Suspension is available in bottle of 120ml.

 

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